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Factors Linked to Age of Onset of Menopause Identified
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THURSDAY, Jan. 26 (HealthDay News) -- Recent genetic factors associated with a woman's age when she begins menopause possess been identified by an international team of researchers. Researchers identified 13 loci (specific location of a gene on a chromosome) linked with immune function as well as DNA repair, which possess an effect on when menopause begins, said the researchers from the Boston University Schools of Community Health as well as Medicine as well as colleagues. They as well as confirmed four previously established loci. For most women, menopause -- the term for the end of reproductive function of the ovaries -- occurs in the beginning 50s. The study was published online Jan. 22 in the journal Nature Genetics. Most previous studies examining age of onset of menopause possess zeroed in on genes associated with the estrogen-production pathway or vascular components, the researchers said. "Our findings demonstrate the role of genes which regulate DNA repair as well as immune function, as well as genes affecting neuroendocrine pathways of ovarian function in regulating age at menopause, indicating the process of aging is involved in both somatic as well as germ line aging," the study authors said. The recent findings "bring us closer to understanding the genetic basis for the timing of menopause. They may as well as provide clues to the genetic basis of beginning onset or premature menopause as well as reduced fertility," team co-leader Kathryn Lunetta, a professor of biostatistics at the BU School of Community Health, said in a university news release. "We hope that as a best understanding of the biologic effects of these menopause-related variants are uncovered, we will gain recent insights into the connections between menopause as well as cardiovascular disease, breast cancer, osteoporosis as well as other traits related to aging, as well as that this will provide avenues for prevention as well as treatment of these conditions," Lunetta said. -- Robert Preidt  Copyright © 2012 HealthDay. All rights reserved.
SOURCE: Boston University Schools of Community Health as well as Medicine, news release, Jan. 23, 2012
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