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2 New Genes Tied to 3 Cancers
2 Recent Genes Tied to 3 CancersTHURSDAY, Aug. 7 (HealthDay News) — Two genes linked to breast, thyroid as well as kidney cancer possess been identified by Cleveland Clinic researchers. The discovery of the genes SDHB as well as SDHD could help improve beginning detection of these cancers as well as boost patients' chances of survival.
In addition, the researchers said their finding could improve screening as well as treatment of patients with Cowden Syndrome (CS) as well as CS-like disease, which are difficult-to-recognize conditions that lead to a high risk of developing breast, thyroid as well as other cancers. Normally, a gene called PTEN acts to suppress cancers. Mutations in PTEN determine susceptibility to CS, but some people with common PTEN still develop CS, according to background information in a clinic news release. The reseaqrchers identified SDHB as well as SDHD as markers of CS susceptibility in people with common PTEN. In fact, mutations in these genes confer a higher risk of breast, thyroid as well as kidney cancers than PTEN mutations for individuals with dysfunctional PTEN, the researchers said. "Clinicians should consider SDH testing for patients who possess a powerful personal history and/or family history of breast, thyroid and/or kidney cancers especially when their PTEN is common. Patients with SDH mutations should be more rigorously screened for these cancers," lead researcher Dr. Chris Eng said in the news release. Rigorous screening may reveal cancer at a earlier, more treatable stage. The study is published in the Aug. 8 issue of The American Journal of Human Genetics. — Robert Preidt SOURCE: Cleveland Clinic, news release, Aug. 7, 2008
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